Federal office of Consumer Protection and Food safetyZKBS

Oncogene database

Welcome to the oncogene database

Here you have the opportunity to inform yourself about cellular and viral genes/nucleic acids that have been assessed in regard to their oncogenic potential by the ZKBS or its office. The hazard potential arising from a protein?s immunomodulatory, neurodegenerative or toxic properties are unrelated to its oncogenic potential and are therefore not assessed. This list is continuously expanded and updated.

Note: Entries of designated oncogenes and/or tumour suppressor genes originating before 01.01.2017 may be outdated due to changed criteria relating to the assessment of oncogenes. You are advised to contact the office of the ZKBS (e.g. via the contact form on the main page) to inquire about the status of such genes.
The following genes/nuclei acids display transforming potential:
  • genes/nuclei acids that enable the anchorage-independent growth of relevant vertebrate cell lines in vitro
  • genes/nucleic acids that induce tumours in animals.
Besides the original literature the following databases are used for the assessment:
registration dateGene/Nuc. acidfunctionclassification
2/27/24PKP3 shRNA Suppression der Expression von PKP3 (siehe Eintrag)without hazard potential
2/27/24PKP3 Gene product associated with desmosome complexes. Involved i ...oncogene
2/26/24PKP2 und shRNA Gene product associated with desmosome complexes. Involved E ...without hazard potential
2/23/24PKP1 und shRNA Gene product isoform 1 is part of the desmosome complexes. I ...without hazard potential
2/2/24FGF2 und shRNA growth factor; ligand of the FGF-receptor family; involved i ...without hazard potential
11/17/23TM6SF2 und shRNA Regulator of liver fat metabolism influencing triglyceride s ...without hazard potential
11/17/23RNF145 und shRNA E3 ubiquitin ligase; catalyzes the direct transfer of ubiqui ...without hazard potential
11/17/23LRP2 und shRNA Multi-ligand endocytic receptor; is expressed in many differ ...without hazard potential
11/17/23CUBN und shRNA Endocytic receptor; plays a role in lipoprotein, vitamin and ...without hazard potential
11/17/23CLCN5 und shRNA Proton-coupled chloride transporter, member of the ClC famil ...without hazard potential
11/17/23ERBB2 shRNA Suppression der Expression von ERBB2 (siehe Eintrag)without hazard potential
11/17/23ERBB2 Protein tyrosine kinase; member of the epidermal growth fact ...oncogene
10/4/23CHD1L shRNA Suppression der Expression von CHD1L (siehe Eintrag)without hazard potential
10/4/23CHD1L DNA helicase; involved in DNA repair. The protein converts A ...oncogene
7/28/23SMARCB1 shRNA Suppression der Expression von SMARCB1 (siehe Eintrag)oncogene
7/28/23SMARCB1 DNA-binding protein; Core component of the BAF (hSWI/SNF) co ...tumour suppressor
7/21/23WNT7B und shRNA Signaling protein; Ligand for members of the frizzled family ...without hazard potential
7/21/23AFM und shRNA Glycoprotein; Member of the albumin gene family, which is co ...without hazard potential
7/20/23NGFR und shRNA Neurotrophin receptor; Nerve growth factor receptor contain ...without hazard potential
7/11/23TOX und shRNA Transcriptional regulator; TOX thymocyte selection associate ...without hazard potential
7/11/23ZEB2 shRNA Suppression der Expression von ZEB2 (siehe Eintrag)without hazard potential
7/11/23ZEB2 transcriptional inhibitor, ZEB2 Zinc finger E-box-binding ho ...oncogene
6/30/23TOX2 und shRNA Putative transcriptional activator; involved in the hypothal ...without hazard potential
6/27/23FYB1 und shRNA FYN-binding protein 1, acts as an adapter protein of the FYN ...without hazard potential
6/27/23POU2F2 und shRNA transcription factor; a homeobox-containing transcription fa ...without hazard potential

Commercial use of the data is not permitted

 Assessment done by the office of the ZKBS

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