ATPase; The encoded protein plays a role in protein degradation, intracellular membrane fusion, DNA repair and replication, regulation of the cell cycle, and activation of the NF-kappa B pathway. This protein forms a homohexameric complex that interacts with a variety of cofactors and extracts ubiquitinated proteins from lipid membranes or protein complexes.
ohne Gefährdungspotential
VCP knockdown was shown to inhibit cell proliferation, chemoresistance and invasion, and induce apoptosis in HCT116 colorectal cancer (CRC) cells, whereas VCP over-expression suppressed apoptosis and chemoresponse, promoted proliferation and invasion of RKO CRC cells. In addition, in the subcutaneous tumor and lung metastasis mouse model, VCP knockdown in HCT116 cells suppressed carcinogenesis and metastasis in vivo.
Die ursächliche Beteiligung an der Entstehung von Tumoren ist nicht gezeigt.
Fu Q et al., Mol Cell Biochem. 2016 Jul;418(1-2):189-98.
