UBXN2A significantly induces apoptosis in the human colon carcinoma cell line HCT-116 and SW48 cells through regulating p53 functions. UBXN2A decreased migration and invasion by nearly 50% in HCT-116 cells compared with empty transfected cells. UBXN2A overexpression decreases the growth of HCT-116 xenografted in micecompared with empty xenografts and untransfected HCT-116.
Die ursächliche Beteiligung an der Entstehung von Tumoren ist nicht gezeigt.
Sane S et al., Cell Death Dis. 2014 Mar 13;5:e1118.
