protein tyrosine phosphatase; The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction.
ohne Gefährdungspotential
It has been demonstrated that PTPRJ is involved in the control of cell growth and adhesion, being furthermore altered in several types of cancer including mammary, thyroid, lung, colon, and pancreatic cancers. Ectopic expression of PTPRJ inhibits cell growth, migration, and invasiveness in the colorectal cancer cell line HCT116. Moreover, PTPRJ inhibits the tumorigenecity of HCT116 in a xenograft mouse tumor model. Neither changes in life span nor spontaneous tumor appearance were observed in Ptprj-null mice.
PTPRJ-deficient meningioma cells exhibited invasive growth in an orthotopic xenotransplantation model in nude mice.
Die ursächliche Beteiligung an der Entstehung von Tumoren ist nicht gezeigt.
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