Suppression der Expression von CAV1 (siehe Eintrag)
Onkogen
Due to its function in the negative regulation of signal transduction, loss of Cav1 has been implicated in the pathogenesis of many cancers. Cav1 overexpression decreases cell and tumor growth, whereas Cav1 knockdown increases these attributes in cutaneous squamous cell carcinoma cells. In addition, Cav1 knockdown increases the invasive ability and incidence of spontaneous lymph node metastasis. NIH 3T3 cells harboring antisense caveolin-1 exhibit anchorage-independent growth. NIH 3T3 cells harboring vector alone did not show foci formation or growth in soft agar. Three of the transformed cell lines were tumorigenic in immuno-deficient strains of mice, forming tumors with high frequency (65–100%). After 2–3 weeks, these tumors reached masses of ~2–4 g. Importantly, no tumors were observed with normal NIH 3T3 cells used for control injections.
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