v-myb is the equivalent of the N- and C-terminally truncated cellular c-Myb protein. v-Myb, the transforming protein of avian myeloblastosis virus, causes acute myeloid leukemia in chickens. Analysis of T cell development in the v-Myb transgenic mice shows that ectopic expression of v-Myb leads to high grade T cell lymphomas in a significant proportion of older animals, demonstrating that v-Myb is oncogenic in T cells.
Badiani PA et al., Oncogene. 1996;13(10):2205-2212.
