Suppression der Expression von CDX2 (siehe Eintrag)
ohne Gefährdungspotential
CDX2 knockdown in colon cancer cells promoted cell proliferation in vitro, accelerated tumor formation in vivo, and induced a cell cycle transition from G0/G1 to S phase, whereas CDX2 overexpression inhibited cell proliferation. In mice, mosaic knockout of Cdx2 in the adult intestinal epithelium induces the formation of imperfect gastric-type metaplastic lesions. The metaplastic knockout cells do not spontaneously become tumorigenic. Heterozygous Cdx2 knockout mice develop hamartomatous polyps in the proximal colon. In adult mice, these hamartomas grew very slowly and took a benign course. None of them progressed into invasive adenocarcinomas, even at 1.5 years of age.
Es ist nicht gezeigt, dass der Funktionsverlust des Gens zur Entstehung von Tumoren führt.
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