Details zum Onkogen
| MIR552 und miRNA* | |
| microRNA 552; MIRN552; hsa-mir-552 | |
| Homo sapiens | |
| MIR552 encoded miRNA regulated the expression of various genes after transcription by directly binding to the 3′UTR of the target gene mRNA. Different MIR552-miRNA target genes are known, among others transcriptional regulators, catalytic enzymes and other mostly regulatory proteins. | |
| ohne Gefährdungspotential | |
| MIR552 expression is up-regulated in many different tumor types [1]. Overexpression of MIR522 in different cancer cell lines increases proliferation [2–6]. In a murine xenograft assay the injection of cancer cell lines transduced with lentiviral vectors coding for a MIR522 mimic results in bigger tumors [2]. Die Ursächliche Beteiligung an der Entstehung von Tumoren ist nicht gezeigt. | |
| [1] Zou, Y. et al., J Cancer, 2020, 11 (21), 6226–6233. doi: 10.7150/jca.46613. [2] Qu, W. et al., J Cell Mol Med, 2019, 23 (2), 1541–1552. doi: 10.1111/jcmm.14062. [3] Huang, M. et al., Tissue Cell, 2021, 73, 101672. doi: 10.1016/j.tice.2021.101672. [4] Zhao, W. et al., J Ovarian Res, 2019, 12 (1), 121. doi: 10.1186/s13048-019-0589-y. [5] Kwak, B. et al., Int J Oncol, 2018, 53 (4), 1800–1808. doi: 10.3892/ijo.2018.4505. [6] Cheng, Z. et al., Exp Cell Res, 2023, 431 (1), 113741. doi: 10.1016/j.yexcr.2023.113741. | |