This gene encodes a dsRNA specific endoribonuclease responsible for miRNA processing in the nucleus.
ohne Gefährdungspotential
DROSHA expression is up-regulated in esophageal and ovarian cancer cells [1,2].
In a transgenic mice modell, neither the knock-out of Drosha or the Knock-in of a human active DROSHA mutant results in formation of tumors.
Die Ursächliche Beteiligung an der Entstehung von Tumoren ist nicht gezeigt.
[1] Sugito, N. et al., Clin Cancer Res, 2006, 12 (24), 7322–7328. doi: 10.1158/1078-0432.CCR-06-0515.
[2] Vaksman, O. et al., Hum Pathol, 2012, 43 (11), 2062–2069. doi: 10.1016/j.humpath.2012.02.016.
