Details zum Onkogen
| NOTCH4 shRNA* | |
| INT3 | |
| Nukleinsäure | |
| Suppression der Expression von NOTCH4 (siehe Eintrag) | |
| ohne Gefährdungspotential | |
| Activation of expression of a recombinant NOTCH4 genomic DNA fragment in HC11 mouse mammary epithelial cells in vitro induces anchorage-independent growth in soft agar [1]. Transgenic mice were generated expressing NOTCH4 as an MMTV-LTR-driven transgene. Focal and often multiple poorly differentiated mammary and salivary adenocarcinomas appeared in the majority of transgenic mice between 2 and 7 months of age [2]. Subcutaneous injection of NOTCH4-transduced metastatic cell line (451Lu) into the right flank of C. B-17/IcrHanHsdArcPrkdcscid mice resulted in a delayed tumor onset of more than 4 days compared with the injection of empty vector control transduced cells [3]. Es ist nicht gezeigt, dass der Funktionsverlust des Gens zur Entstehung von Tumoren führt. | |
| [1] Robbins, J. et al., J Virol, 1992, 66 (4), 2594–2599. doi: 10.1128/jvi.66.4.2594-2599.1992. [2] Jhappan, C. et al., Genes Dev, 1992, 6 (3), 345–355. doi: 10.1101/gad.6.3.345. [3] Bonyadi Rad, E. et al., Cancer Res, 2016, 76 (7), 1690–1697. doi: 10.1158/0008-5472.CAN-15-1722. | |