Regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content. May function as sterol isomerase. Located in endoplasmic reticulum membrane and endoplasmic reticulum-Golgi intermediate compartment membrane.
ohne Gefährdungspotential
Hepatocyte-specific deletion of TM6SF2 in mice enhanced liver tumorigenesis in two models of HCC, either neonatal mice injected with Streptozotocin and high fat-diet or with diethylnitrosamine injection plus high trans-fat fructose (TFF) diet feeding. Tm6sf2 LKO mice had greater tumor burden and increased tumor area compared with WT mice [1].
Die ursächliche Beteiligung an der Entstehung von Tumoren ist nicht gezeigt.
[1] Newberry, E. P. et al., Hepatology, 2021, 74 (3), 1203–1219. doi: 10.1002/hep.31771.
