Details zum Onkogen
| ERBB2 shRNA* | |
| NEU; NGL; HER2; TKR1; CD340; HER-2; VSCN2; MLN 19; MLN-19; c-ERB2; c-ERB-2; HER-2/neu; p185(erbB2) | |
| Nukleinsäure | |
| Suppression der Expression von ERBB2 (siehe Eintrag) | |
| ohne Gefährdungspotential | |
| The 6.2 Kb erbb2 mRNA is overexpressed in certain mammary tumor cell lines [1]. Overexpression of ERBB2 coding sequences in NIH 3T3 cells resulted in cellular transformation (anchorage-independent growth) and tumorigenesis of athymic mice [2,3]. | |
| [1] Slamon, D. J. et al., Science, 1989, 244 (4905), 707–712. doi: 10.1126/science.2470152. [2] Di Fiore, P. P. et al., Science, 1987, 237 (4811), 178–182. doi: 10.1126/science.2885917. [3] Hudziak, R. M. et al., Proc Natl Acad Sci U S A, 1987, 84 (20), 7159–7163. doi: 10.1073/pnas.84.20.7159. | |