Suppression der Expression von CHD1L (siehe Eintrag)
ohne Gefährdungspotential
CHD1L ubiquitous-expression transgenic mouse model was generated. Spontaneous tumor formations were found in 10/41 (24.4%) transgenic mice, but not in their 39 wild-type littermates over a monitoring period of 22 months. [1]
CHD1L was stably expressed in the mouse fibroblast cell line NIH3T3. Tumor xenograft experiments in nude mice were performed and tumor formation was observed in 4 of 6 and 0 of 6 CHD1L-transfected and blank vector transfected NIH3T3 cells, respectively. [2]
[1] Chen, M. et al., PLoS One, 2009, 4 (8), e6727. doi:10.1371/journal.pone.0006727.
[2] Ji, X. et al., J Surg Res, 2013, 185 (1). doi: 10.1016/j.jss.2013.05.008.
