Details zum Onkogen
PKP3* | |
Mensch/Maus/Ratte | |
Gene product associated with desmosome complexes. Involved in modulation of cell cycle progression. | |
Onkogen | |
PKP3 is overexpressed in certain pancreatic and ovarian cancer cells [1,2]. Overexpression of PKP3 coding sequences in primary murine keratinocytes resulted in cellular transformation (anchorage-independent growth) [3]. | |
[1] Lim, V. et al., Biochem Biophys Res Commun, 2019, 508 (2), 646–653. doi: 10.1016/j.bbrc.2018.11.163. [2] Du, Y. et al., Biomedicines, 2023, 11 (9). doi: 10.3390/biomedicines11092472. [3] Müller, L. et al., Cell Rep, 2023, 42 (1), 112031. doi: 10.1016/j.celrep.2023.112031. | |