putative methyltransferase; May be involved in the assembly and release stages of hepatitis C virus (HCV) life cycle and thus play a crucial role in HCV propagation.
ohne Gefährdungspotential
Overexpression of METTL7A in SNU-449 and SNU-398 cells significantly reduced the cell viability, frequency of focus formation, and the number of colonies formed in soft agar. Xenograft tumors derived from 398-M7A cells, with overexpression of METTL7A, grew much slower.
Specific shRNAs-mediated silencing of METTL7A augmented the tumorigenicity of Huh-7 cells (increased cell viability and higher frequency of colony formation in soft agar). Xenograft tumors derived from stably knockdown cells (Huh7-shM7A b) grew much more aggressively than tumors derived from control cells (Huh7-shCTL).
Die ursächliche Beteiligung an der Entstehung von Tumoren ist nicht gezeigt.
Qi L, Nucleic Acids Res. 2017 Oct 13;45(18):10436-10451. doi: 10.1093/nar/gkx667
