The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis.
ohne Gefährdungspotential
A human squamous carcinoma cell line, with high TSP production and an invasive phenotype, was transfected with a TSP cDNA antisense expression vector. The resulting clones demonstrated reduced growth rates in vitro when compared with a vector transfected control. After subcutaneous inoculation into athymic mice, the antisense clones formed either no tumors or tumors that were slow growing and highly differentiated.
THBS1 depletion inhibited migration and invasion of CRC cells through attenuating epithelial-mesenchymal transition.
bEND.3 cells rapidly proliferate in culture and express little or no thrombospondin 1 (TS1). bEND.3 cells were stably transfected with a human TS1 expression vector. The cells expressing human TS1 were readily identified by their altered morphology and exhibited a slower growth rate and lower saturation density than the parental bEND.3 cells. Moreover, while the bEND.3 cells formed large tumors in nude mice within 48 hr, the TS1-expressing cells failed to form tumors even after 1 month.
Die ursächliche Beteiligung an der Entstehung von Tumoren ist nicht gezeigt.
Castle V et al., J Clin Invest. 1991 Jun;87(6):1883-8. doi: 10.1172/JCI115212
Liu X et al., Clin Transl Oncol. 2020 Oct;22(10):1730-1740. doi: 10.1007/s12094-020-02308-8
Sheibani N et al., Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):6788-92. doi: 10.1073/pnas.92.15.6788
