DNA-binding protein; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex).
ohne Gefährdungspotential
Overexpression of SMARCE1 markedly promoted the proliferation, migration, and invasion of gastric cancers cells in vitro and tumorigenesis in vivo.
Knockdown of SMARCE1 reduced proliferation, colony formation, and tumorigenicity of neuroblastoma cells.
Die ursächliche Beteiligung an der Entstehung von Tumoren ist nicht gezeigt.
Liu H et al., Cancer Manag Res. 2019 Apr 23;11:3493-3509.
Hu X et al., Oncogene. 2022 Aug 17. doi: 10.1038/s41388-022-02428-1
