RNA-binding protein; May play a role in a ERBB3-regulated signal transduction pathway. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly.
ohne Gefährdungspotential
Ectopic expression of PA3G4 in ErbB-2, ErbB-3-expressing breast carcinoma cell lines resulted in inhibition of colony formation, a decreased proliferation rate, an accumulation of cells in the G2/M phase of the cell cycle, and suppression of growth in soft agar.
Die ursächliche Beteiligung an der Entstehung von Tumoren ist nicht gezeigt.
Lessor TJ et al., J Cell Physiol. 2000 Jun;183(3):321-9.
