Suppression der Expression von PCGF2 (siehe Eintrag)
ohne Gefährdungspotential
MEL18 contributes to the development of colitis-associated cancer in mice by promoting proliferation and reducing apoptosis via suppressing expression of Reg3b. Downregulation of Mel-18 in human medulloblastoma xenografts results in tumor growth retardation in vivo. Overexpression of Mel-18 allowed anchorage-independent growth of Rat1 fibroblasts.
The self-renewal of breast cancer stem cells (CSCs) was enhanced by Mel-18 knockdown, as measured by the ability for tumorsphere formation in vitro and tumor-initiating capacity in vivo. Similarly, Mel-18 overexpression inhibited the number and self-renewal activity of breast CSCs in SK-BR-3 cells.
Die ursächliche Beteiligung an der Entstehung von Tumoren als Tumorsuppressorgen ist nicht gezeigt.
Liu X et al., Gastroenterology. 2017 Dec;153(6):1607-1620.
Wiederschain D et al., Mol Cell Biol. 2007 Jul;27(13):4968-79.
Won HY et al., FASEB J. 2012 Dec;26(12):5002-13.
Guo WJ et al., Cancer Res. 2007 Jun 1;67(11):5083-9.
