zinc finger protein; Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum. It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum. It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed. May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation
Tumorsuppressor
AIRAPL expression is widely abrogated in human myeloproliferative disorders. AIRAPL-deficient mice develop a fully-penetrant myeloproliferative neoplasm.
Osorio FG et al., Nat Med. 2016 Jan;22(1):91-6.;
Osorio FG et al., Cell Cycle. 2016;15(7):873-4.
