Ubiquitin-protein ligase; Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation.
ohne Gefährdungspotential
UBE4B promoted the degradation and ubiquitination of p53 to inhibit the apoptosis of cancer cells and promote tumorigenesis in breast cancer.
Die ursächliche Beteiligung an der Entstehung von Tumoren ist nicht gezeigt.
Zhang Y et al., PLoS One. 2014 Feb 26;9(2):e90154.
