protein binding protein; Bridging factor that mediates the recruitment of the deubiquitinase CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis. Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD
ohne Gefährdungspotential
nicht beschrieben
Schlicher L et al., Cell Death Differ. 2017 Jul;24(7):1142-1147.
