cell adhesion protein; may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions.
ohne Gefährdungspotential
Inactivation of VE-cadherin triggered a significant loss of malignant traits (proliferation, adhesion, invasion and transendothelial migration) in melanoma and breast cancer cells. Knocking down VE-cadherin suppressed lung colonization capacity of melanoma or breast cancer cells inoculated in mice.
Die ursächliche Beteiligung an der Entstehung von Tumoren ist nicht gezeigt.
Bartolomé RA et al., Oncotarget. 2017;8(1):215-227.
