cell adhesion protein; May act as a negative regulator of neural cell growth.
ohne Gefährdungspotential
H-cadherin expression is lost in nearly 80% of the analyzed melanoma cell lines. Knockdown of H-cadherin using siRNA increases invasive capacity in melanocytes. Functional assays show that the re-expression of H-cadherin decreases migration and invasion capacity, as well as anchorage-independent growth in comparison to control melanoma cells. Furthermore, melanoma cells, which re-express H-cadherin via stable transfection show a reduction in rate of tumor growth in a nu/nu mouse tumor model in comparison to the parental control transfected cell lines. H-cadherin transfection produced a marked inhibition of tumor growth and modified the morphology of tumor cells: tumors from mice injected with control cells were significantly larger and contained larger cells having a higher degree of pleomorphism than those of tumors generated from carcinoma cells expressing H-cadherin.
Die ursächliche Beteiligung an der Entstehung von Tumoren ist nicht gezeigt.
Die vorsorgliche Einstufung als Tumorsuppressor ist damit aufgehoben.
Kuphal S et al., Pigment Cell Melanoma Res. 2009;22(3):296-306.
Lee SW et al., Carcinogenesis. 1998;19(6):1157-1159.
