Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Acts as a mRNA splicing regulator. Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes.
ohne Gefährdungspotential
WTAP promoted the proliferation capability and tumor growth of hepatocellular carcinoma cells in vitro and in vivo. In ovarian cancer cell lines, cell proliferation and migration were considerably reduced after WTAP was down-regulated, while apoptotic rate was increased. WTAP regulates migration and invasion of glioblatoma cells. Specific knockdown by siRNA or overexpression by cDNA regulated migration and invasion of these cancer cells. In xenograft study, WTAP overexpression made these cancer cells more tumorigenic. Overexpression or knockdown of WTAP significantly increased or decreased the motility of cholangiocarcinoma cells. Moreover, WTAP overexpression or knockdown significantly increased or decreased tumorigenicity of cholangiocarcinoma cells in an orthotopic xenograft model.
Die ursächliche Beteiligung an der Entstehung von Tumoren ist nicht gezeigt.
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