Ribosome biogenesis factor; Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase. May be a transcriptional regulator.
ohne Gefährdungspotential
RNA interference-mediated inhibition of CIRH1A expression significantly suppressed proliferation and increased apoptosis of transduced RKO colorectal cancer cells, and tended to arrest them in G1 phase.
Die ursächliche Beteiligung an der Entstehung von Tumoren ist nicht gezeigt.
Guo F et al., Oncol Rep. 2017 Apr;37(4):2375-2381.
