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RBM3 shRNA* |
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RNPL; IS1-RNPL shRNA |
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Nukleinsäure |
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Suppression der Expression von RBM3 (siehe Eintrag) |
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ohne Gefährdungspotential |
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RBM3 mRNA and protein are upregulated in human tumors. RBM3 promotes hepatocellular carcinoma cell proliferation. RBM3 overexpression induces anchorage-independent growth of NIH3T3 cells. Downregulating RBM3 with short interfering RNA (siRNA) decreases HCT116 colon adenocarcinoma cell proliferation. Furthermore, downregulating RBM3 in nude mice tumor xenografts decreased angiogenesis. |
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Dong W et al., EBioMedicine. 2019 Jul;45:155-167.
Sureban SM et al., Oncogene. 2008 Jul 31;27(33):4544-56. |
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