mRNA binding protein; enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances phosphorylation of translation initiation factors and active polysome formation
Onkogen
RBM3 mRNA and protein are upregulated in human tumors. RBM3 promotes hepatocellular carcinoma cell proliferation. RBM3 overexpression induces anchorage-independent growth of NIH3T3 cells. Downregulating RBM3 with short interfering RNA (siRNA) decreases HCT116 colon adenocarcinoma cell proliferation. Furthermore, downregulating RBM3 in nude mice tumor xenografts decreased angiogenesis.
Dong W et al., EBioMedicine. 2019 Jul;45:155-167.
Sureban SM et al., Oncogene. 2008 Jul 31;27(33):4544-56.
